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KMID : 0370019950090000123
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Chung-Ang Journal of Pharmacal Sciences
1995 Volume.9 No. 0 p.123 ~ p.137
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The Effect of Allopurionl on the Arachidonic Acid Induced Platelet Aggregation in Rat and Pulmonary Thromboembolism in Mice
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Abstract
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This study was performed to free radical scavenging of xanthine-oxidase inhibitor, allopurinol.
In pulmonary thromboembolism in mice, intraperitoneal administration of allopurinol decreased dose-dependently mortality or paralysis by intravenous infusion of collagen plus epinephrine. But, Ca^2+ antagonists (p.o.) did not cause significant decrease in thromboembolism. Among Ca^2+ antagonists, nifedipine with allopurinol decreased significantly thrombotic challenge.
In arachidonic acid (AA)-induced platelet aggreagtion, allopurinol only caused inhibition platelet aggregation at 10^-3 M. Pyrogallol increased AA-induced platelet aggregation by superoxide anion production. Allopurinol at any concentration decreased significantly the increment of AA-induced platelet aggregation by pyrogallol.
In conclusion, allopurinol had the mechanism of free radical scavenging other than xanthine oxidase inhibition and had the activity to be show protection on the pulmonary thromboembolism with vasodilator.
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